Moist Mississippi Meatloaf

Section: Satisfying Main Dishes for Every Occasion

This Mississippi-inspired meatloaf is slow-cooked to achieve a moist and tender texture, blending ground beef with traditional seasoning mixes like au jus and ranch, plus tangy peperoncini peppers that add depth without heat. Mixed seasonings are incorporated into the meat for full-flavor infusion, while a luscious gravy is poured over before cooking. The rich gravy is thickened after cooking for a perfect finish. Serve slices with mashed potatoes or steamed veggies for a hearty meal.

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Brought to You By Nina
Last updated on Sun, 25 Jan 2026 19:39:58 GMT
A plate of food with meatloaf and mashed potatoes. Bookmark
A plate of food with meatloaf and mashed potatoes. | ninatable.com

Crock Pot Mississippi Meatloaf is a tender and moist meatloaf bursting with the signature flavors of Mississippi cooking. With the rich combination of au jus ranch seasoning and peperoncini peppers this dish elevates classic meatloaf into something truly special. The slow cooker makes preparation effortless while infusing the meat with its delicious seasoning and creating a savory gravy for serving.

I remember making this one chilly weekend when I was craving comfort food. The aroma filled the house and by dinner everyone was asking for seconds.

Ingredients

  • Milk: two percent or higher fat content helps bind the meat and keep everything moist
  • Eggs: well beaten to ensure they mix smoothly into the meat and improve texture
  • Granulated sugar: balances the salty and tangy flavors in the dish for a harmonious taste
  • Au jus gravy mix: adds a savory depth, if unavailable onion soup mix is a fine substitute
  • Ranch seasoning mix: provides that characteristic creamy herb flavor essential for true Mississippi style
  • Panko breadcrumbs: soak up moisture and keep the meatloaf from getting dense, regular breadcrumbs can be used in a pinch
  • Lean ground beef: eighty five fifteen or ninety ten lets you enjoy flavor without excessive grease
  • Cold water and peperoncini juice: together make the flavorful gravy that soaks the meatloaf
  • Peperoncini peppers: whole not chopped bring a mild tang and essential Mississippi zing without overwhelming heat
  • Cornstarch and water slurry: thicken the gravy for a silky finish

Instructions

Line the crock pot:
Spoon a large piece of foil into a six or eight quart crock pot lining the bottom and sides gently pressing it in place. Spray the foil with nonstick cooking spray. This makes cleanup easier and helps lift the meatloaf out after cooking
Combine wet and dry ingredients:
Whisk together one cup of milk two percent or higher two large well beaten eggs two teaspoons of granulated sugar one packet each of au jus gravy mix and ranch seasoning mix plus one cup of panko breadcrumbs in a large mixing bowl until fully combined. This creates the flavor base and texture binder for the meat
Add beef:
Add two pounds of lean ground beef to the mixture and gently mix using your hands or a large spoon just until combined. Avoid overmixing so the meatloaf stays tender and does not become tough
Shape in crock pot:
Transfer the meat mixture into the foil lined crock pot and shape into a smooth oval using your hands or spatula. This shape promotes even cooking and mimics the classic meatloaf silhouette
Make the gravy:
In a separate bowl whisk together three cups of cold water one quarter cup of peperoncini juice the remaining packet each of au jus gravy mix and ranch seasoning mix until blended well. This will be the gravy poured over and around the meatloaf
Assemble and top:
Pour the prepared gravy over the meatloaf in the crock pot making sure it covers the sides as well. Top the meatloaf carefully with six whole peperoncini peppers spaced evenly across the top. These add signature flavor and visual appeal
Cook:
Cover the crock pot and cook on low for five to six hours or on high for three to four hours until the internal temperature reaches one hundred sixty five degrees Fahrenheit to ensure safety and juiciness
Remove carefully:
Using two spatulas carefully lift the meatloaf out of the crock pot onto a serving dish. Lifting with the foil sides is tricky because of the gravy so spatulas help avoid spills and keep it intact
Strain gravy:
Strain the remaining liquid from the crock pot into a medium sized saucepan or pot to remove any small meat bits and create a smooth gravy
Thicken gravy:
Whisk together two tablespoons of cornstarch and two tablespoons of water in a small bowl until smooth to make a slurry. Bring the strained gravy to a gentle simmer over medium heat then slowly stir in the slurry while continuously whisking. Let the sauce simmer for one minute until thickened
Serve:
Slice the meatloaf and serve with the prepared gravy spooned generously over each portion. This completes the hearty and flavorful meal
A plate of meatloaf with gravy.
A plate of meatloaf with gravy. | ninatable.com

My favorite ingredient here has to be the peperoncini peppers. They add just the right tang without heat and give the dish its unmistakable Mississippi character. The first time I made this my whole family was amazed at how the humble pepper transformed the meatloaf. It quickly became a go to recipe for cozy weekend dinners.

Storage Tips

Store leftover meatloaf and gravy separately when possible in an airtight container. Refrigerate for up to three days or freeze for up to three months to enjoy later. Reheat gently in the slow cooker or cover in foil and warm in the oven to preserve moisture and flavor.

Ingredient Substitutions

If you cannot find au jus gravy mix onion soup mix is an excellent alternative and will still yield great flavor. Regular breadcrumbs can replace panko though the texture might be a little denser. You can swap ground beef for ground turkey chicken or pork with some flavor adjustments as lean meat alters grease content in the gravy.

Serving Suggestions

Serve slices draped in gravy alongside creamy mashed potatoes and steamed seasonal vegetables like peas and carrots. Biscuits or crusty bread are great for sopping up leftover gravy. For a twist try serving the meatloaf over egg noodles or fluffy rice to soak in every bit of flavor.

A crock pot with meatloaf and peppers.
A crock pot with meatloaf and peppers. | ninatable.com

This Crock Pot Mississippi Meatloaf is the ultimate comfort meal ready with minimal hands on time. Enjoy with mashed potatoes and plenty of gravy.

Common Recipe Questions

→ Why is butter omitted in this meatloaf?

The ground beef’s natural fat provides enough richness, so no additional butter is needed for flavor.

→ How is the seasoning incorporated for best flavor?

Seasoning packets are mixed into the meat mixture instead of sprinkled on top to infuse flavor throughout the meatloaf.

→ Are the peperoncini peppers spicy?

Peperoncini peppers offer tangy flavor but are not spicy when kept whole. Adjust quantity to your spice tolerance.

→ What sides complement this meatloaf?

Mashed potatoes, steamed vegetables, rice, or egg noodles pair well with the meatloaf and its savory gravy.

→ Can the gravy be strained?

Yes, straining removes meat bits from the gravy for a smoother texture, though it's optional based on preference.

→ Can this be prepared ahead of time?

Yes, you can prepare the meat mixture a day ahead, refrigerate it, then cook just before serving.

Tender Mississippi Meatloaf

A slow-cooked tender meatloaf with bold Mississippi flavors and a rich, savory gravy.

Prep Time
10 minutes
Cooking Time
360 minutes
Total Time
370 minutes
Brought to You By: Nina

Recipe Category: Main Dishes

Skill Level: Great for Beginners

Cuisine Type: American

Portions: 8 Serves

Dietary Preferences: ~

What You'll Need

→ Dairy and Eggs

01 1 cup 2% milk
02 2 large eggs, well beaten

→ Seasonings and Mixes

03 2 teaspoons granulated sugar
04 2 packets (1 oz each) au jus gravy mix, divided use
05 2 packets (1 oz each) ranch seasoning mix, divided use

→ Dry Ingredients

06 1 cup panko breadcrumbs

→ Meat

07 2 pounds lean ground beef (85/15 or 90/10)

→ Liquids

08 3 cups cold water
09 1/4 cup peperoncini juice

→ Vegetables

10 6 peperoncini peppers

→ Thickening Agent

11 2 tablespoons cornstarch
12 2 tablespoons water

Steps to Follow

Step 01

Line a 6- or 8-quart slow cooker with a large piece of foil extending up the sides and spray with nonstick cooking spray.

Step 02

In a large bowl, whisk together milk, eggs, granulated sugar, one packet each of au jus gravy mix and ranch seasoning mix, and panko breadcrumbs until fully combined.

Step 03

Add ground beef to the mixture and combine gently with clean hands, taking care not to overmix to avoid toughness.

Step 04

Transfer the mixture to the slow cooker and shape it into an oval loaf.

Step 05

In a separate bowl, whisk cold water, peperoncini juice, and the remaining packets of au jus gravy and ranch seasoning mix until well combined.

Step 06

Pour the prepared gravy evenly over and around the meatloaf, then arrange peperoncini peppers on top.

Step 07

Cook on low for 5 to 6 hours or on high for 3 to 4 hours, until internal temperature reaches 165°F (74°C).

Step 08

Carefully lift the meatloaf from the slow cooker using two spatulas and place on a serving dish.

Step 09

Strain cooking juices into a medium saucepan and heat over medium. Whisk cornstarch and water to create a slurry, then gradually whisk into simmering gravy. Cook for 1 minute until thickened, then remove from heat.

Step 10

Slice the meatloaf and spoon the thickened gravy over each serving.

Extra Suggestions

  1. Use 2% or higher fat milk for best moisture and texture.
  2. Do not overmix ground beef to maintain tenderness.
  3. Straining the gravy removes meat bits for a smooth sauce.
  4. Store leftovers separately with gravy refrigerated up to 3 days or frozen up to 3 months.
  5. Peperoncini peppers add flavor but minimal heat; omit juice if sensitive to spice.

Tools You’ll Need

  • 6 or 8-quart slow cooker
  • Large mixing bowls
  • Whisk
  • Measuring cups and spoons
  • Medium saucepan
  • Spatulas

Allergy Details

Read ingredient lists for allergens carefully, and consult a healthcare provider if you're unsure.
  • Contains egg, dairy, and wheat (breadcrumbs)

Nutritional Details (Per Serving)

The provided nutrition information is for guidance and shouldn't replace expert medical advice.
  • Calories: 250
  • Fat: 8 grams
  • Carbohydrates: 14 grams
  • Proteins: 28 grams